Failure to escape shock following repeated exposure to inescapable shock

Failure to escape traumatic shock.

Dogs which had 1st learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box. In contrast, yoked, inescapable shock in the harness produced profound interference with subsequent escape responding in the shuttle box. Initial experience with escape in the shuttle box led to enhanced panel pressing during ines...

Effects of inescapable shock upon subsequent escape and avoidance responding.

Exposure of dogs to inescapable shocks under a variety of conditions reliably interfered with subsequent instrumental escape-avoidance responding in a new situation. Use of a higher level of shock during instrumental avoidance training did not attenuate interference; this was taken as evidence against an explanation based upon adaptation to shock. Ss curarized during their exposure to inescapab...

Inescapable shock induces resistance to the effects of dexamethasone.

Administration of bacterial endotoxin (lipopolysachharide; LPS) elevates proinflammatory cytokines, such as interleukin-1beta (IL-1beta) and IL-6, and activates the hypothalamic-pituitary-adrenal (HPA) axis. Corticosterone (CORT), the glucocorticoid (GC) effector hormone of the HPA axis in rats, inhibits both proinflammatory cytokine production/release and activity of the HPA axis itself. Expos...

Electric shock in patients administered to hospital: a descriptive study

Escape from shock versus escape from shock accompanied by a visual stimulus in rats.

Two groups of 15 rats each were trained in a shuttle box to escape foot-shock either unsignalled or presented in compound with a visual cue: darkness. The visual cue presented in shock compartment amplifies the behavioral tendency actually prevailing in the response repertory of the rat. During the 1st session the compound enhanced the species-specific flight resulting in shortening of the rat'...